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Combining Dual 3D Bioprinting and Regional Bioactive Factors to Make Vascularized Bone Construct
GW researchers generated a vascularized and highly osteogenic bone construct with a biphasic structure using a multiple 3D printing platform. Traditional tissue engineering techniques face major obstacles in creating multiple tissue structures and vascularization of tissues. 3D bioprinting allows for control over the location of cells and biomaterials;...
Published: 1/7/2022
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Updated: 10/26/2021
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Inventor(s): Haitao Cui, Wei Zhu, Lijie Zhang
Keywords(s):
Category(s): Technology Classifications > Medical Devices > Regenerative Medicine
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Thick 3D Bioprinted Cardiac Patch with Anisotropic and Perfusable Vessels
GW researchers fabricated a vascularized patch of cardiac tissue suitable for cardiac regeneration using 3D bioprinting. Cardiovascular disease involving myocardial infarction is a major cause of morbidity and mortality worldwide. Following myocardial infarction, adult cardiac tissue cannot significantly repair or regenerate itself. Current therapies...
Published: 1/7/2022
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Updated: 10/26/2021
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Inventor(s): Lijie Zhang, Haitao Cui, Yimin Huang
Keywords(s):
Category(s): Technology Classifications > Medical Devices > Cardiology
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4D-Printed Programmable Culture Substrate for Controlling Neural Stem Cell Growth
Neural stem cells (NSCs) exhibit great promise for treating neurodegenerative diseases and injuries. Treatments will rely on efficient proliferation and differentiation of NSCs into neurons with therapeutic characteristics. Static 2D and 3D microenvironment culture substrates fail to cater to the dynamic cell needs, resulting in sub-optimal, inefficient...
Published: 1/7/2022
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Updated: 10/26/2021
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Inventor(s): Shida Miao, Haitao Cui, Lijie Zhang
Keywords(s):
Category(s): Technology Classifications > Research Tools > Buffers and Media
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3D printed vascularized tissue scaffold with extracellular matrix triggered growth factor release
Vas-Scaf” is a 3D bio-printed vascularized bone scaffold perfused with osteogenic and angiogenic growth factors. Artificial bone grafts lacking vascularization fail due to poor integration of new tissues with the host and death of interior bone tissues. Bone and blood vessel tissues require different support structures and different biochemical...
Published: 1/7/2022
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Updated: 10/14/2021
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Inventor(s): Haitao Cui, Wei Zhu, Benjamin Holmes, Lijie Zhang
Keywords(s):
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Therapeutics > Nanoparticles, Technology Classifications > Industrial or Consumer Tech > Materials
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3D Printing Blood Vessels Without Sacrificial Templates
Using novel bioactive ink for 3D printing, GW researchers create multi-layered vasculature. Large-scale artificial tissue implants for defect reconstruction require vascularization to avoid interior necrosis, but blood vessel printing remains challenging.
Current 3D bioprinting methods for creating vasculature mainly utilize sacrificial templates to...
Published: 1/7/2022
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Updated: 10/14/2021
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Inventor(s): Haitao Cui, Lijie Zhang, Wei Zhu
Keywords(s):
Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Industrial or Consumer Tech > Materials, Technology Classifications > Therapeutics > Cells
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