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Prostate Cancer Diagnostics and Therapeutics Based on Differential Gene Splicing

Many more African Americans (AA) die from prostate cancer than Caucasian Americans (CA), even after factoring in socioeconomic influences. The NIH designated identifying medically relevant differences in these populations as a high priority research area. Inventors at GWU identified differences in gene splicing between AA and CA prostate cancer samples....

Published: 1/7/2022 | Updated: 11/13/2021 | Inventor(s): Norman Lee, Steven Patierno, Bi-Dar Wang

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Therapeutics > RNA

Companion Diagnostics and Compound Screening Assay for PI3K Inhibitors

The phosphatidylinositol 3-kinase (PI3K) protein family regulates cellular functions including growth, proliferation, survival, differentiation, and motility. Because these functions are critical for cancer progression, many companies are developing therapeutic compounds to inhibit PI3K. GW inventors identified an alternative splicing variant of PIK3CD...

Published: 1/7/2022 | Updated: 11/13/2021 | Inventor(s): Norman Lee, Bi-Dar Wang, Steven Patierno

Keywords(s):

Category(s): Technology Classifications > Therapeutics > Proteins and Peptides