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Immunotherapies Targeting SSX2 Peptide Displayed by MHC on Tumors
Chimeric Antigen Receptor (CAR) T cells are making headlines with their recent FDA approvals and ability to eradicate cancers. Most CAR T therapies target tumor cells via a tumor associated antigen (TAA). Unfortunately, TAAs are also expressed on non-cancerous tissues, leading to significant risk for patients. SSX2 protein expression is restricted...
Published: 1/7/2022
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Updated: 11/16/2021
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Inventor(s): Eric Yvon, Catherine Bollard, Stacey Van Pelt, Scott Raskin
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Proteins and Peptides
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Companion Diagnostics and Compound Screening Assay for PI3K Inhibitors
The phosphatidylinositol 3-kinase (PI3K) protein family regulates cellular functions including growth, proliferation, survival, differentiation, and motility. Because these functions are critical for cancer progression, many companies are developing therapeutic compounds to inhibit PI3K. GW inventors identified an alternative splicing variant of PIK3CD...
Published: 1/7/2022
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Updated: 11/13/2021
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Inventor(s): Norman Lee, Bi-Dar Wang, Steven Patierno
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Proteins and Peptides
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Thinking outside the heart: Use of engineered cardiac tissue for treatment of chronic deep venous insufficiency
Researchers at George Washington University invented a new organ that can return blood flow to veins lacking functioning valves. The organ is a rhythmic cuff made of cardiac muscle cells that surrounds the vein. The cuff acts as a “mini heart” to aid blood flow through the venous segments. It can be made of a patient’s own adult...
Published: 1/7/2022
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Updated: 11/9/2021
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Inventor(s): Narine Sarvazyan
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > Proteins and Peptides
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Antisense RNA therapy for liver carcinoma
A GW researcher invented a nucleic acid based therapy for Hepatitis C Virus (HCV) infection associated hepatocellular carcinoma (HCC, liver cancer). Currently available antiviral drugs can only eliminate short term effects of the HCV. But liver damage, caused by chronic HCV infections, carries the very high risk of developing into hepatocellular carcinoma,...
Published: 1/7/2022
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Updated: 11/9/2021
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Inventor(s): Ajit Kumar, Nagarajan Pattabiraman
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > Proteins and Peptides, Technology Classifications > Therapeutics > RNA
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Intranasal Oxytocin Therapy for Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a health risk that occurs in 24% of males and 9% of females in the United States. OSA can lead to several cardiovascular diseases including hypertension, arrhythmia, and stroke. Continuous positive airway pressure (CPAP) treatments often fail due to low compliance.
GW Researchers developed an intranasal oxytocin administration...
Published: 1/7/2022
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Updated: 11/4/2021
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Inventor(s): David Mendelowitz, Heather Jameson, Vivek Jain, Jay Kimbro
Keywords(s):
Category(s): Technology Classifications > Medical Devices > Cardiology, Technology Classifications > Therapeutics > Proteins and Peptides
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Intranasal Oxytocin to Treat Heart Failure
Heart failure (HF) results in imbalance of the cardiac autonomic system, i.e. increased sympathetic activity and decreased parasympathetic activity. The present therapies for heart failure only decrease sympathetic activity and have many side effects. There is no drug or device that restores parasympathetic activity.
GW researchers found a new method...
Published: 1/7/2022
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Updated: 10/26/2021
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Inventor(s): Matthew Kay, David Mendelowitz, Jhansi Dyavanapalli, Kara Garrott, Gregory Trachiotis
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Proteins and Peptides
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Optimization of Cold Atmospheric Plasma-Stimulated Media for Treatment of Cancer
Previously, GW researchers invented a method to selectively kill cancer cells with cold atmospheric plasma (CAP) while leaving neighboring normal cells intact. In a subsequent study, the researchers showed that similar anti-cancer effects can be achieved indirectly using CAP-stimulated media (CAPSM).
Stability of CAPSM (preservation of its anti-cancer...
Published: 1/7/2022
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Updated: 10/14/2021
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Inventor(s): Dayun Yan, Michael Keidar, Jonathan Sherman
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > Proteins and Peptides, Technology Classifications > Therapeutics
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