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HDAC6i-Activated Macrophage Cell Therapy
The tumor microenvironment (TME) plays a key role in tumor growth and survival. Often the immunosuppressive nature of the TME prevents success of treatments including immune checkpoint blockade (ICB), radiation therapy (RT), and chemotherapy. Macrophages in the TME contribute to its immunosuppressive or immunostimulatory character. M2 macrophages...
Published: 1/7/2022
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Updated: 11/23/2021
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Inventor(s): Alejandro Villagra, Nima Aghdam, Satish Noonepalle
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells
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(Technology Bundle) Stem cells with transiently reduced p53 to treat diabetes associated kidney disease and peripheral vascular disease
Local delivery of endothelial progenitor cells (EPCs) may treat diabetic-related kidney disease (DKD) and peripheral vascular disease (PVD). EPCs may be obtained from a patient’s peripheral blood. The hyperglycemic state in diabetic patients causes transplanted EPCs to undergo apoptosis, creating a challenge for such therapies. By transiently...
Published: 1/7/2022
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Updated: 11/16/2021
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Inventor(s): Sabyasachi Sen
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells
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Amplified Bimorph Scanning Mirror, Optical System and Method of Scanning
Over ninety percent of all human cancers arise in epithelial tissues. Several imaging techniques including MRI, ultrasound and optical coherence tomography (OCT) and elastography are used to detect cancers. However, the resolution of MRI and ultrasound is too low for the imaging of epithelial tissues. When compared with MRI and ultrasound, OCT has...
Published: 1/7/2022
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Updated: 11/16/2021
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Inventor(s): Patrick Mills, Jason Zara, Stephen Smith, Paul Patterson
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Research Tools > Imaging Tools
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Novel Compounds that Target Mycobacteria and Other Pathogenic Bacteria
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is one of the deadliest infectious diseases. Emergence of drug resistant strains of Mtb and co-infection with HIV has made TB both difficult and expensive to treat. New TB therapies are needed to shorten treatment and be effective against all strains and metabolic states of the organism....
Published: 1/7/2022
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Updated: 11/16/2021
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Inventor(s): Cynthia Dowd, Kylene Kehn-Hall, Helena Boshoff, Richard Lee, Emily Jackson, Geraldine San Jose, Robin Lee
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > Repurposed Drugs, Technology Classifications > Therapeutics > Small Molecules
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Thinking outside the heart: Use of engineered cardiac tissue for treatment of chronic deep venous insufficiency
Researchers at George Washington University invented a new organ that can return blood flow to veins lacking functioning valves. The organ is a rhythmic cuff made of cardiac muscle cells that surrounds the vein. The cuff acts as a “mini heart” to aid blood flow through the venous segments. It can be made of a patient’s own adult...
Published: 1/7/2022
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Updated: 11/9/2021
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Inventor(s): Narine Sarvazyan
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > Proteins and Peptides
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Antisense RNA therapy for liver carcinoma
A GW researcher invented a nucleic acid based therapy for Hepatitis C Virus (HCV) infection associated hepatocellular carcinoma (HCC, liver cancer). Currently available antiviral drugs can only eliminate short term effects of the HCV. But liver damage, caused by chronic HCV infections, carries the very high risk of developing into hepatocellular carcinoma,...
Published: 1/7/2022
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Updated: 11/9/2021
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Inventor(s): Ajit Kumar, Nagarajan Pattabiraman
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > Proteins and Peptides, Technology Classifications > Therapeutics > RNA
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3D Shape Memory Scaffolds for Tissue Engineering
Over 120,000 patients are currently waiting for lifesaving organ and tissue transplants. Tissue engineering has the potential to innovate transplant and minimally invasive surgery by creating tissue substitutes from biopolymers with human stem cells.
GW researchers developed a plant oil infused biopolymer with unique characteristics that are highly...
Published: 1/7/2022
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Updated: 11/4/2021
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Inventor(s): Shida Miao, Wei Zhu, Nathan Castro, Lijie Zhang
Keywords(s):
Category(s): Technology Classifications > Industrial or Consumer Tech > Materials, Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > Small Molecules
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(Technology Bundle) Stem cells with transiently reduced p53 to treat diabetes associated kidney disease and peripheral vascular disease
Local delivery of endothelial progenitor cells (EPCs) may treat diabetic-related kidney disease (DKD) and peripheral vascular disease (PVD). EPCs may be obtained from a patient’s peripheral blood. The hyperglycemic state in diabetic patients causes transplanted EPCs to undergo apoptosis, creating a challenge for such therapies. By transiently...
Published: 1/7/2022
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Updated: 10/26/2021
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Inventor(s): Sabyasachi Sen
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells
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Diagnostic method for detecting bacterial/viral infections by host RNA levels in blood
In instances of respiratory distress, it is often difficult to determine whether an infection is present or if the distress is purely inflammatory in nature. Treatments for these conditions differ greatly (either with antibiotics for infection or with anti-inflammatory drugs in case of no infection), although symptoms can often be similar. Currently,...
Published: 1/7/2022
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Updated: 10/26/2021
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Inventor(s): Timothy McCaffrey, Lakhmir Chawla
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > RNA
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Therapeutics to prevent HIV-associated Coronary Artery Disease
HIV-infected patients have high risk of coronary artery disease (CAD). Previously, GW researchers identified HIV regulatory protein Nef as a causative factor in foam cell formation, a precursor condition to CAD. Currently, GW researchers developed compounds that show Nef-neutralizing effects in vitro. The prototype compounds restore cholesterol efflux...
Published: 1/7/2022
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Updated: 10/26/2021
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Inventor(s): Michael Bukrinsky, Ruth Hunegnaw, Alexei Adzhubei
Keywords(s):
Category(s): Technology Classifications > Medical Devices > Cardiology, Technology Classifications > Therapeutics > Cells
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