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Novel Compounds that Target Mycobacteria and Other Pathogenic Bacteria
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is one of the deadliest infectious diseases. Emergence of drug resistant strains of Mtb and co-infection with HIV has made TB both difficult and expensive to treat. New TB therapies are needed to shorten treatment and be effective against all strains and metabolic states of the organism....
Published: 1/7/2022
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Updated: 11/16/2021
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Inventor(s): Cynthia Dowd, Kylene Kehn-Hall, Helena Boshoff, Richard Lee, Emily Jackson, Geraldine San Jose, Robin Lee
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > Repurposed Drugs, Technology Classifications > Therapeutics > Small Molecules
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Antibiotic for Veterinary Staphylococcal Infections
New bacteriostatic compounds treat Staphylococcal strains that infect bovine, cat, and dog populations. Staphylococcal infections affect an estimated 20% of bovine populations in the dairy industry, and are the single largest indication for antibiotic use on dairy farms. Staphylococcal infections lead to a cost of greater than $1 billion per year...
Published: 1/7/2022
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Updated: 10/26/2021
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Inventor(s): Cynthia Dowd, Audrey Odom, Rachel Edwards
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Small Molecules
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New Use for Small Molecule to Kill Malaria Parasites
GW researchers synthesized the new small molecule, RCB-185, and initially showed efficacy against Mycobacterium tuberculosis (Mtb), but now demonstrate much higher efficacy against malaria. According to the World Health Organization, 2015 had 212 million cases of malaria with 429,000 deaths. People desperately need new treatments for malaria, as use...
Published: 1/7/2022
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Updated: 10/14/2021
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Inventor(s): Cynthia Dowd, Robert Brothers, Audrey Odom, Rachel Edwards
Keywords(s):
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Therapeutics > Small Molecules
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