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Novel Compounds that Target Mycobacteria and Other Pathogenic Bacteria
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is one of the deadliest infectious diseases. Emergence of drug resistant strains of Mtb and co-infection with HIV has made TB both difficult and expensive to treat. New TB therapies are needed to shorten treatment and be effective against all strains and metabolic states of the organism....
Published: 1/7/2022
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Updated: 11/16/2021
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Inventor(s): Cynthia Dowd, Kylene Kehn-Hall, Helena Boshoff, Richard Lee, Emily Jackson, Geraldine San Jose, Robin Lee
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > Repurposed Drugs, Technology Classifications > Therapeutics > Small Molecules
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3D Shape Memory Scaffolds for Tissue Engineering
Over 120,000 patients are currently waiting for lifesaving organ and tissue transplants. Tissue engineering has the potential to innovate transplant and minimally invasive surgery by creating tissue substitutes from biopolymers with human stem cells.
GW researchers developed a plant oil infused biopolymer with unique characteristics that are highly...
Published: 1/7/2022
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Updated: 11/4/2021
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Inventor(s): Shida Miao, Wei Zhu, Nathan Castro, Lijie Zhang
Keywords(s):
Category(s): Technology Classifications > Industrial or Consumer Tech > Materials, Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > Small Molecules
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JAK2 Inhibition to Treat Platinum Resistant Ovarian Cancer
Researchers at GW overcame platinum drug resistance in ovarian cancer by combining JAK2 inhibitor LY2784544 with standard platinum based chemotherapeutics. Doctors commonly prescribe platinum-based drugs, like cisplatin, to treat ovarian cancer. Over time many patients become resistant to the treatment and succumb to the disease. Doctors need new options...
Published: 1/7/2022
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Updated: 10/26/2021
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Inventor(s): Wenge Zhu, Wei Zhou, Wei Zheng, Wei Sun
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Small Molecules
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In vitro drug treatment to proliferate and activate effector cells for immunotherapy
STAT5 SUMOylation inhibition increases CD4 and CD8 T-cell proliferation and and production of immune effector molecules in CD8 T-cells and NK (natural killer) cells. Both attributes address critical limiting factors in applying cell therapies to fighting cancers and pathogens. The difficulty of obtaining enough activated effector cells limits the...
Published: 1/7/2022
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Updated: 10/26/2021
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Inventor(s): Alberto Bosque-Pardos, Amanda Beatriz Rodrigues Barreto de Macedo, Eric Sorensen, Vicente Planelles
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Small Molecules
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And-1 Inhibition by DHS for Cancer Treatment
GW researchers developed DHS (4,4’-trans-dihydroxystilbene) as a new cytotoxic anticancer drug for use alone or in combination with other chemotherapies. Drug toxicity and drug resistance limit the ability of many cytotoxic cancer drugs to effectively treat cancer, a problem which is overcome by DHS. The cancer killing efficacy of DHS is...
Published: 1/7/2022
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Updated: 10/26/2021
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Inventor(s): Chi-Wei Chen, Zhiyong Han, Wenge Zhu, Yongming Li
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Small Molecules
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Antibiotic for Veterinary Staphylococcal Infections
New bacteriostatic compounds treat Staphylococcal strains that infect bovine, cat, and dog populations. Staphylococcal infections affect an estimated 20% of bovine populations in the dairy industry, and are the single largest indication for antibiotic use on dairy farms. Staphylococcal infections lead to a cost of greater than $1 billion per year...
Published: 1/7/2022
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Updated: 10/26/2021
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Inventor(s): Cynthia Dowd, Audrey Odom, Rachel Edwards
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Small Molecules
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New Use for Small Molecule to Kill Malaria Parasites
GW researchers synthesized the new small molecule, RCB-185, and initially showed efficacy against Mycobacterium tuberculosis (Mtb), but now demonstrate much higher efficacy against malaria. According to the World Health Organization, 2015 had 212 million cases of malaria with 429,000 deaths. People desperately need new treatments for malaria, as use...
Published: 1/7/2022
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Updated: 10/14/2021
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Inventor(s): Cynthia Dowd, Robert Brothers, Audrey Odom, Rachel Edwards
Keywords(s):
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Therapeutics > Small Molecules
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