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JAK2 Inhibition to Treat Platinum Resistant Ovarian Cancer

Researchers at GW overcame platinum drug resistance in ovarian cancer by combining JAK2 inhibitor LY2784544 with standard platinum based chemotherapeutics. Doctors commonly prescribe platinum-based drugs, like cisplatin, to treat ovarian cancer. Over time many patients become resistant to the treatment and succumb to the disease. Doctors need new options...

Published: 1/7/2022 | Updated: 10/26/2021 | Inventor(s): Wenge Zhu, Wei Zhou, Wei Zheng, Wei Sun

Keywords(s):

Category(s): Technology Classifications > Therapeutics > Small Molecules

And-1 Inhibition by DHS for Cancer Treatment

GW researchers developed DHS (4,4’-trans-dihydroxystilbene) as a new cytotoxic anticancer drug for use alone or in combination with other chemotherapies. Drug toxicity and drug resistance limit the ability of many cytotoxic cancer drugs to effectively treat cancer, a problem which is overcome by DHS. The cancer killing efficacy of DHS is...

Published: 1/7/2022 | Updated: 10/26/2021 | Inventor(s): Chi-Wei Chen, Zhiyong Han, Wenge Zhu, Yongming Li

Keywords(s):

Category(s): Technology Classifications > Therapeutics > Small Molecules