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Laser Ablation Electrospray Ionization (LAESI) Mass Spectrometry: matrix-free ambient 2D or 3D imaging of living tissue without sample preparation
LAESI provides very precise in situ chemical analysis of biological samples using mass spectrometry (MS) technique. LAESI enables 2D and 3D imaging of metabolites, lipids, peptides and proteins in biological samples at the single cell level, empowering rapid chemical analyses in multiple fields of biology, medicine and chemistry. The LAESI device embodies...
Published: 1/7/2022
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Updated: 11/16/2021
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Inventor(s): Akos Vertes, Peter Nemes
Keywords(s):
Category(s): Technology Classifications > Research Tools > Imaging Tools
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Amplified Bimorph Scanning Mirror, Optical System and Method of Scanning
Over ninety percent of all human cancers arise in epithelial tissues. Several imaging techniques including MRI, ultrasound and optical coherence tomography (OCT) and elastography are used to detect cancers. However, the resolution of MRI and ultrasound is too low for the imaging of epithelial tissues. When compared with MRI and ultrasound, OCT has...
Published: 1/7/2022
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Updated: 11/16/2021
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Inventor(s): Patrick Mills, Jason Zara, Stephen Smith, Paul Patterson
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Research Tools > Imaging Tools
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Matrix-free Mass Spectrometry on Nanopost Array (NAPA) Chips
Silicon NAPA chips provide highly efficient ion production for ultratrace analysis and molecular imaging by mass spectrometry without an ionization matrix. Matrix-assisted laser desorption ionization (MALDI) is an established ionization technique for mass analysis of large biomolecules, but analysis of small biomolecules (m/z < 1000) suffers from...
Published: 1/7/2022
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Updated: 10/26/2021
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Inventor(s): Akos Vertes, Bennett Walker, Jessica Stolee, Scott Retterer, Deanna Pickel
Keywords(s):
Category(s): Technology Classifications > Research Tools > Imaging Tools
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